Read Bottle of Lies: The Inside Story of the Generic Drug Boom By Katherine Eban

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Bottle of Lies: The Inside Story of the Generic Drug Boom-Katherine Eban

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A NEW YORK TIMES BESTSELLER New York Times 100 Notable Books of 2019New York Public Library Best Books of 2019 Kirkus Reviews Best Health and Science Books of 2019Science Friday Best Books of 2019 New postscript by the authorFrom an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticalsMany have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true?Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?  A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles. 

Book Bottle of Lies: The Inside Story of the Generic Drug Boom Review :



As a pharmacist, I was looking forward to reading Katherine Eban’s new book about generic drugs. I know her to be an excellent researcher and a great author. Having just finished the book, I can say I was not disappointed. At least I was not disappointed in the author. She did a wonderful job as usual! The book is well researched and documented, and it reads like a novel. It would make a great movie as well!It was, however, very disappointing (shocking, disturbing!), to learn about the negligence and outright fraud associated with the manufacture of many generic drugs and the lack of oversight and public protection provided by the federal agency that is supposed to regulate these products, the U.S. Food and Drug Administration (FDA). About 90% of medications consumed in the United States are generics and the vast majority of these are made in India and China. The FDA is responsible to inspect and regulate plants that make medicines for use in the U.S., including plants outside the U.S. While the book highlights some dedicated and highly competent FDA employees, they often failed to receive support from higher in the agency.Key lessons from this book:--Don’t assume that all generic drugs are equivalent to brand name products, especially those that are supposed to release the ingredients slowly over time (e.g. products ending with “LA”, “SR”, or “XL”).--Political considerations sometimes trump public health and patient safety concerns at the FDA. Where is the accountability for the organization? House Energy and Commerce Committee members should read this book!--Along with accountability, the FDA needs more resources and funding. Since 2005, the number of plants and medicines manufactured outside the U.S. has exceeded the number inside the U.S. The FDA needs to be like the State Department, with dedicated international employees who understand the language and culture and reside for longer terms in other countries.I highly recommend this book to anyone who takes generic medicines, is considering taking generic medicines, or is involved in health policy. This should cover about 95% of Americans.
The author's attention to detail is as welcome as her commitment to the patients of our world. This book's details may be slandered but not denied. It does not pull any punches when it relates the events in numerous pharma plants all over the planet. It is evident that the author has lived the subject of her book for many years. I was particularly pleased with the details regarding Dr. Dinesh Thakur's integrity and commitment to Vedic dharmic principles.Where this book does pull its punches however is when it comes to raising suspicions about institutional corruption within the FDA.That was most certainly a moral obligation that this book failed to fulfill despite clear indications of back-room shenanigans that allowed Ranbaxy to get a new drug application approved, allowed CEO Malvinder to escape criminal prosecution despite the smoking guns handed to the United States by Dr. Thakur at grave personal risk (The US Attorney was.... Rod Rosenstein), returning to giving the criminals 6-weeks notice of FDA inspections, and most terrifying of all, allowing the caught-in-the-act criminals to continue their fraud in other pharma companies, thereby spreading the muck to even previously-good companies like Mylan.FDA officials are exclusively and individually responsible for that terrible outcome, as is HHS Inspector General Daniel Levinson.

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